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Ipidacrine hydrochloride hydrate

CAS No. 118499-70-0

Ipidacrine hydrochloride hydrate ( Amiridine;NIK 247 )

Catalog No. M10628 CAS No. 118499-70-0

Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ipidacrine hydrochloride hydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.
  • Description
    Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.Alzheimer Disease Phase 3 Discontinued
  • Synonyms
    Amiridine;NIK 247
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    AChE
  • Recptor
    AChE
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    118499-70-0
  • Formula Weight
    242.75
  • Molecular Formula
    C12H19ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CCC2=C(C1)C(=C3CCCC3=N2)N.O.Cl
  • Chemical Name
    2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride hydrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nabeshima T, et al. Eur J Pharmacol. 1988 Sep 23;154(3):263-9.
2. Onodera K, et al. Nihon Shinkei Seishin Yakurigaku Zasshi. 1998 Apr;18(2):33-7.
3. Kojima J, et al. Gen Pharmacol. 1998 Aug;31(2):297-300.
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