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Ipidacrine hydrochloride hydrate
CAS No. 118499-70-0
Ipidacrine hydrochloride hydrate( Amiridine | NIK 247 )
Catalog No. M10628 CAS No. 118499-70-0
Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIpidacrine hydrochloride hydrate
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NoteResearch use only, not for human use.
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Brief DescriptionIpidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.
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DescriptionIpidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels; enhances not only choline, but also adrenaline, serotonin, histamine, and oxytocin effects on smooth muscle.Alzheimer Disease Phase 3 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAmiridine | NIK 247
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number118499-70-0
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Formula Weight242.747
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Molecular FormulaC12H19ClN2O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CCC2=C(C1)C(=C3CCCC3=N2)N.O.Cl
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Chemical Name2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride hydrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nabeshima T, et al. Eur J Pharmacol. 1988 Sep 23;154(3):263-9.
2. Onodera K, et al. Nihon Shinkei Seishin Yakurigaku Zasshi. 1998 Apr;18(2):33-7.
3. Kojima J, et al. Gen Pharmacol. 1998 Aug;31(2):297-300.
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